Which of the following amendments addresses issues of self-incrimination?

The Fifth Amendment is the correct choice as it specifically addresses issues of self-incrimination. This amendment provides several protections for individuals, one of the most important being that no person "shall be compelled in any criminal case to be a witness against himself." This means that individuals have the right to remain silent and cannot be forced to testify against themselves in a way that could incriminate them.

The Fifth Amendment also encompasses due process and protection against double jeopardy, but its provision regarding self-incrimination is particularly significant in legal proceedings. This principle is foundational to the criminal justice system, ensuring that accused individuals are not coerced into providing evidence that could lead to their own conviction.

In contrast, the Second Amendment focuses on the right to bear arms, the Fourth Amendment deals with protection against unreasonable searches and seizures, and the Sixth Amendment guarantees the right to a fair trial, the right to counsel, and the right to confront witnesses. Each of these amendments serves its own purpose, but only the Fifth Amendment directly addresses the issue of self-incrimination.